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Profluent, an Emeryville-based AI biotech startup founded in 2022 by Ali Madani, raised $106 million on November 19, 2025, led by Altimeter Capital and Bezos Expeditions, bringing its total funding to $150 million and valuing it at nearly $1 billion. The company has achieved breakthroughs like the AI-designed OpenCRISPR-1 system for precise genome editing and ProGen models generating functional proteins. The new funds will scale computational resources for massive protein datasets and advance applications in therapeutics, agriculture, and materials.

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Jeff Bezos's investment fuels Profluent's quest to design proteins and genome editors using AI, pushing biotech boundaries.

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The House Oversight Committee, led by Chairman James Comer, agreed with former President Bill Clinton and Hillary Clinton on depositions set for late February, avoiding a contempt vote after they resisted subpoenas. The probe examines Jeffrey Epstein's sex-trafficking network, government file handling, and new details like photos of Bill Clinton with Ghislaine Maxwell and emails showing her role in Clinton Global Initiative funding. Republicans highlight flight logs and photos to press questions, while Clinton demands public hearings and full document releases; Maxwell invoked the Fifth over 100 times in her deposition and denied wrongdoing by the Clintons.

Key Takeaway

Bill Clinton called it a 'kangaroo court,' but Republicans are pushing ahead with closed-door depositions to dig into his Epstein ties.

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The Brazilian forward, who joined Chelsea from Brighton last summer, came off the bench to score and assist in the 3-2 victory over West Ham last month, helping the Blues sit fifth with 44 points from 26 games. With manager Liam Rosenior's approval, Pedro, Palmer, Cucurella, and others enjoyed a team-bonding break before hosting Burnley on February 21. Fans praised the downtime for boosting chemistry, though some joked about hangovers impacting sprints, while clips showed Cucurella looking sharp despite his recent hamstring injury.

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Fresh off scoring his 10th Premier League goal in a comeback win, Joao Pedro hit the Dubai nightclub with Cole Palmer and Marc Cucurella, dancing under neon lights to Nigerian hits.

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Huffines, a former state senator running to cut government waste, saw his family's 2023 buy of the 10,000-acre New Mexico property—renamed San Rafael Ranch—ignite controversy due to its Epstein ties and recent abuse allegations from victims like Annie Farmer and Virginia Giuffre. Supporters note the public auction sale four years after Epstein's death funded victim settlements, with Huffines planning a Christian retreat and offering full cooperation to authorities. Critics, including GOP leaders, call it poor judgment amid unverified rumors, as early voting runs through February 28 before the March 3 primary.

Key Takeaway

As early voting began Monday in Texas's Republican primary for state comptroller, Don Huffines' family purchase of Jeffrey Epstein's former Zorro Ranch drew sharp criticism from all sides.

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In a January 17 speech, Bukele dismissed investing in education for gang members who've 'graduated from the university of crime,' pointing to El Salvador's homicide rate plummeting from 106 per 100,000 in 2015 to a record low 1.3 in 2025 after mass arrests of over 80,000 suspects and a massive prison. Supporters like Elon Musk and U.S. Senator Mike Lee praise the results as a model for safer streets, while critics from Amnesty International and Human Rights Watch highlight arbitrary detentions, torture reports, and over 260 detainee deaths since 2022. Bukele's approach, followed by a quip about a pickpocket caught '3 Doritos later,' underscores his push for swift enforcement amid global divides on crime and rights.

Key Takeaway

Surrounded by security forces and seated prisoners, El Salvador's President Nayib Bukele declared criminals beyond redemption by education—only force works.

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John Smith led Labour from July 1992 until his sudden heart attack death on May 12, 1994, at age 55, boosting the party to double-digit poll leads with his dry wit, Christian faith, and traditional values. He sidelined modernizers like Mandelson, earning praise as the 'best prime minister we never had' and 'last honest leader' from voices across the spectrum. The nostalgia surges now as Prime Minister Keir Starmer, who briefly appointed then sacked Mandelson as US ambassador, faces resignation calls after his chief of staff quit over the hire. While most mourn a lost era of integrity, a few question if Smith's government would have endured longer than past short-lived Labour terms.

Key Takeaway

As fresh Epstein revelations force Peter Mandelson's resignation, a post recalls John Smith—the Labour leader who kept him at arm's length during his principled 22-month tenure.

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Reports today detail problems like password changes, failed recoveries, and account restrictions across PayPal, Google, LinkedIn, and Payoneer. Unauthorized transactions held up funds in some PayPal cases, while LinkedIn users dealt with repeated lockouts. No outages or breaches show on status pages, with experts pointing to phishing, weak passwords, or old leaks like the 15 million PayPal credentials exposed earlier this year. Platforms urge quick recovery tries, two-factor setup, and official support contacts for fixes.

Key Takeaway

One person lost access to a Gmail account from 2007, despite every recovery step they knew. Others faced unauthorized logins and locked PayPal funds, turning frustration into urgent pleas for help.

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Protests against Iran's regime entered their second month after exploding on January 8, following Reza Pahlavi's call for unified action amid economic hardship and resentment. Security forces face accusations of massacring thousands, with human rights groups like Amnesty International documenting over 6,000 deaths since late December and up to 36,000 in early January alone. Pahlavi, son of the last shah, seeks a transitional role for free elections, drawing fervent support but also debate over monarchy versus republic, as seen in diaspora rallies and polls. Meanwhile, President Trump noted progress in indirect nuclear talks with Iran on February 7.

Key Takeaway

Chants of 'Long live the King' echo through Iran's streets as protesters wave the old Lion and Sun flag, defying gunfire in a fight for change.

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Vibe coding lets anyone build software quickly using casual AI prompts, popularized by Andrej Karpathy for rapid prototypes with tools like Cursor and Claude. Enthusiasts, including YC's Garry Tan, praise it for speeding up startups with voice inputs and auto DevOps. But critics highlight maintenance costs, reliability issues for enterprises, debugging nightmares, and the need for marketing—arguing polished SaaS tools like Rippling still dominate for scale and compliance.

Key Takeaway

Yuchen Jin sarcastically asked why solo founders aren't vibe-coding full enterprise suites like Slack and Jira over a weekend. His post drew hundreds of likes and replies unpacking the trend's real limits.

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A popular post from February 16 showed seven Spanish midfield legends—Xavi Hernández, Andrés Iniesta, Sergio Busquets, Xabi Alonso, Cesc Fàbregas, David Silva, and Rodri—and asked which one to bench. Rodri supporters highlight his 2024 Ballon d'Or, Spain's Euro 2024 win, Manchester City's treble, and a 74-game unbeaten streak, calling him the complete defensive midfielder who tops stats in tackles, passes, and duels. Critics defend the 2008-2012 icons for their Euros and World Cup triumphs, labeling Rodri's era easier, while many rank Xavi and Iniesta highest but give Rodri the edge over others. The back-and-forth pits fresh achievements against golden-era legacy.

Key Takeaway

Imagine Spain's ultimate midfield seven: Xavi, Iniesta, Busquets, and more. Fans can't agree who sits out—especially with Rodri's Ballon d'Or glow.

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