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Profluent, an Emeryville-based AI biotech startup founded in 2022 by Ali Madani, raised $106 million on November 19, 2025, led by Altimeter Capital and Bezos Expeditions, bringing its total funding to $150 million and valuing it at nearly $1 billion. The company has achieved breakthroughs like the AI-designed OpenCRISPR-1 system for precise genome editing and ProGen models generating functional proteins. The new funds will scale computational resources for massive protein datasets and advance applications in therapeutics, agriculture, and materials.

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Jeff Bezos's investment fuels Profluent's quest to design proteins and genome editors using AI, pushing biotech boundaries.

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At the launch of Shahrukhz by Danube, a 55-storey commercial tower on Sheikh Zayed Road, Khan called the AED 2.1 billion project a pinnacle of his journey. The event sold out instantly, with fans cheering his performance of hits like "Jhoome Jo Pathaan" alongside Farah Khan. Recent honors include his National Film Award for "Jawan" in September and a spot on The New York Times' 2025 list of 67 Most Stylish People for his Met Gala look. Dubai, a longtime hub for his business and family, now features this skyline symbol of his global reach.

Key Takeaway

Shah Rukh Khan stood before thousands in Dubai, voice thick with emotion as he reflected on a bronze DDLJ statue in London, a National Award, and now a towering building bearing his name. For the Bollywood star whose parents passed early in his career, it felt like a moment they could watch proudly from above.

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The Jacobin article, posted by Netanyahu without comment on Friday, cites U.S. documents and leaked emails claiming Epstein boasted of aiding Barak's bid against him, including business ties and unverified intelligence links. Barak dismissed it as nonsense from an antisemitic source during a security forum in Canada, noting their meetings began publicly in 2003 via Shimon Peres and were business-focused. Bennett condemned the share for amplifying conspiracy theories that hurt Israel's security, confirming with ex-Mossad chiefs that no such U.S. operations occurred. The exchange highlights ongoing political tensions, with no official intelligence response and Epstein's claims unverified.

Key Takeaway

Israeli leaders clashed publicly after Prime Minister Netanyahu shared a report alleging Jeffrey Epstein's involvement in Ehud Barak's 2019 election campaign. The move drew swift backlash from former PM Naftali Bennett, who called it deeply harmful.

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In a January 17 speech, Bukele dismissed investing in education for gang members who've 'graduated from the university of crime,' pointing to El Salvador's homicide rate plummeting from 106 per 100,000 in 2015 to a record low 1.3 in 2025 after mass arrests of over 80,000 suspects and a massive prison. Supporters like Elon Musk and U.S. Senator Mike Lee praise the results as a model for safer streets, while critics from Amnesty International and Human Rights Watch highlight arbitrary detentions, torture reports, and over 260 detainee deaths since 2022. Bukele's approach, followed by a quip about a pickpocket caught '3 Doritos later,' underscores his push for swift enforcement amid global divides on crime and rights.

Key Takeaway

Surrounded by security forces and seated prisoners, El Salvador's President Nayib Bukele declared criminals beyond redemption by education—only force works.

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Reports today detail problems like password changes, failed recoveries, and account restrictions across PayPal, Google, LinkedIn, and Payoneer. Unauthorized transactions held up funds in some PayPal cases, while LinkedIn users dealt with repeated lockouts. No outages or breaches show on status pages, with experts pointing to phishing, weak passwords, or old leaks like the 15 million PayPal credentials exposed earlier this year. Platforms urge quick recovery tries, two-factor setup, and official support contacts for fixes.

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One person lost access to a Gmail account from 2007, despite every recovery step they knew. Others faced unauthorized logins and locked PayPal funds, turning frustration into urgent pleas for help.

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Pahlavi, son of Iran's last shah, urged global action against what he called a massacre amid protests sparked by economic collapse and demands to topple Supreme Leader Ali Khamenei. Demonstrations erupted December 28, 2025, spreading to hundreds of cities with chants for regime change and his return; violence peaked January 8-9 as snipers and machine guns killed crowds, with death tolls estimated from 3,000 by the government to over 30,000 by leaked sources and activists. An internet blackout hides the full scale, but reports describe mass burials, over 41,000 arrests, and medics witnessing blood-soaked bodies; Pahlavi vowed freedom is near as exiles plead for U.S. help under new President Trump.

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On January 27, Reza Pahlavi watched Holocaust Remembrance Day images and saw echoes in Iran's streets, where security forces gunned down protesters by the thousands.

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Fizzy strips away the complexity of tools like Trello or Jira, offering clean columns and cards in a freemium model: 1,000 cards free forever, or $20 monthly for unlimited use and support. The entire codebase sits on GitHub under the O'Saasy License, allowing free downloads, modifications, self-hosting, or even sales—with one limit: no rival SaaS services using its features. Developers quickly submitted pull requests, while DHH defends the approach as true open source, pushing back against purists who call it source-available due to the commercial restriction.

Key Takeaway

37signals just unveiled Fizzy, a no-frills kanban tool built for quick bug tracking or podcast workflows. It pairs a simple hosted service with fully public code anyone can tweak.

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Joel Carmona Roa, a citizen of Spain from the Dominican Republic, entered the U.S. via the Visa Waiver Program and overstayed his authorization. ICE Newark arrested him during a targeted operation on Woodbridge Center Drive in Woodbridge, New Jersey. He is an international fugitive wanted in Spain for sexually assaulting a child.

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